Clarithromycin (DCI) .................................... 500 mg
They are limited in adults with infections caused by germs identified as sensitive, including:
- Tonsillitis and pharyngitis,
- Acute sinusitis,
- Acute bronchial fistulae,
- Secondary infections of chronic bronchitis,
- Acute pneumonia,
- Benign skin infections.
Curative treatment of Mycobacterium avium in patients infected with HIV (+).
- Allergy to macrolides.
- Alkaloids of vasoconstrictor ergot (ergotamine and dihydroergotamine) and terfenadine.
- Pregnancy and lactation.
- Bromocriptine and triazolam.
WARNINGS AND PRECAUTIONS
In the treatment of Mycobacterium avium infections in HIV (+) patients, and to limit the emergence of resistant strains, clarithromycin should be used:
- In combination with other antibiotics, not alone,
- In case of severe hepatic impairment. If it is needed, then it warrants regular monitoring liver function tests.
- In patients with renal insufficiency, longer made, a reduction in dosage.
- In the elderly.
- Gastrointestinal events: nausea, vomiting, stomach pains diarrhea.
- Skin Allergic reactions.
- Allergic skin increases.
DOSAGE AND ADMINISTRATION
- Tonsillitis, pharyngitis and mild skin infections:
500mg per day.
- Acute sinusitis and pneumonia 1000mg / d or 2 tablets morning and night
- Bronchial Infections:
500mg and 1000mg / d depending on the severity.
- Infections with Mycobacterium avium in HIV (+) patients:
• 2000mg / day in subjects> 50 kg
• 1500mg / day in subjects ≤ 50kg
• For values of creatinine clearance <30 ml / min, it may be recommended to reduce the dose by half (from 250mg to 500mg / day depending on the type of infection) with once daily administration.
In infection or Mycobacterium avium, it is recommended to use a dose of 1000 mg / d.
When renal function is markedly reduced, it may be prudent to reduce the dosage.
Store at a temperature below 30.degree.
Registration no.: 08L-558